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189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level

Acknowledgements This work was supported by the National Natural Science Foundation of China (82504878 and 82474218), National Administration of Traditional Chinese Medicine (zyyzdxk-2023004), and China Postdoctoral Science Foundation (2024M752181)

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